SOCR 3D Cell Morphometry Project

Cell nuclear morphology is regulated by complex underlying biological mechanisms related to cell differentiation, development, proliferation, and disease. Changes in the nuclear form are associated with reorganization of chromatin architecture related to altered functional properties such as gene regulation and expression. Thus, nuclear morphological quantification becomes of major relevance as studies of chromatin and DNA architecture reorganization emerge. In this project, we produced imaging datasets and proposed new methodological approaches that combine modeling, analysis, and interpretation of morphometric characteristics of cell nuclei and other compartments in 3D.

Publications:

Data and code:

Data: see data download page

Source code and workflow protocols: see GitHub repository